Pathology Chap 13: THE HAEMATOPOIETIC SYSTEM

Syllabus:
X. Haematology:
[1] Constituents of blood and bone marrow, Regulation of hematopoiesis.
[2] Anaemia: Classification, clinical features and lab diagnosis.
[3] Nutritional anaemias: Iron deficiency anemia; Folic acid, Vit. B 12 deficiency anemia including pernicious anaemia.

[4] Hemolytic Anaemias: classification and investigations.
Pathologic features of following types:
a. Hereditary Hemolytic Anaemias: Thalassemia, Sickle cell anaemia, Spherocytosis and enzyme deficiencies.

b. Acquired Hemolytic Anaemias:
i. Alloimmune, Autoimmune
ii. Drug induced, Microangiopathic.
[5] Pancytopenia- Aplastic anemia (Causes, pathogenesis, investigations)
[6] Haemostatic disorders, Vascular and Platelet disorders & lab diagnosis.
[7] Coagulopathies-Types: (i) Inherited, (ii) Acquired, with lab diagnosis.
[8] Leucocytic disorders: Leucocytosis, Leukopenias, Leukaemoid reaction.
(Etiology, types, pathogenesis & investigation of each type)
[9] Leukaemia: Classification, clinical manifestation, pathology and Diagnosis.
[11] Blood transfusion: Grouping and cross matching, untoward reactions, transmissible infections including HIV & hepatitis, Blood-components & plasma-pheresis.

[12] Myelodysplastic syndromes- Basic concepts. Etiology, Types, Pathogenesis & Investigations to be sent.
[13] Myeloproliferative disorders: Polycythemia, Myelofibrosis- basic concepts. Etiology, Types, Pathogenesis & Investigations to be sent.

Questions:
LE:
1. Define and classify anaemias. Discuss the laboratory diagnosis of megaloblastic anaemia. [1+3+5=9] [RS Sept 02, P1], [RS Nov 00, P1]
2. Mention 2 conditions where you get spherocytes in peripheral smear. Discuss the etiology and diagnosis of hereditary Spherocytosis. [1+8=9]
[RS Mar 04, P1]
3. Classify Haemolytic anaemias. Describe Sickle cell anaemia. [RS May 00, P1]
4. Define and classify leukaemia. Describe the laboratory diagnosis of acute myeloid leukaemia. [1+3+5=9] [RS Oct 03, P1]
5. Define Purpura. Describe the classification of purpuras. Describe the bone marrow picture of sickle cell anaemias. [RS May 00, P1]
6. Classify bleeding disorders. Describe the pathogenesis and lab findings of Idiopathic thrombocytopenic purpura. [3+2+4] [RS Mar 03, P1]

SE:
1. Classification of anaemia. [RS Mar 06, P1]
2. Laboratory findings in megaloblastic anaemia. [RS Mar 06, P1],
[RS Dec 04, P1]
3. Laboratory diagnosis of megaloblastic anaemia. [RS Mar 05, P1]
4. Megaloblastic bone marrow. [RS Oct 03, P1]
5. Classification of haemolytic anaemia. [OS Apr 01]
6. Molecular pathogenesis of beta thalassaemia. [OS May 00]
7. Myelodysplastic syndrome. [RS Mar 03, P1]
8. Leukaemoid blood reaction. [RS Sept 02, P1]
9. Write a note on leukaemoid reactions. [OS Apr 02]
10. FAB classification of leukaemia. [RS Mar 05, P1]
11. Cytochemistry of acute leukaemias. [RS Mar 03, P1]
12. Chronic myeloid leukaemia. [RS Dec 04, P1]
13. Haemolytic findings in chronic lymphocytic leukaemia. [OS Sept 02]
14. Haemophilia. [RS Mar 03, P1]
15. Von-Willebrand disease. [RS Mar 06, P1], [RS Sept 02, P1]
16. Prothrombin time. [RS Oct 03, P1]
17. List the causes of thrombocytopenia. [OS May 00]
18. Drug induced thrombocytopenia. [OS Sept 02]
19. Haemolytic disease of newborn. [RS Mar 03, P1]
20. Erythroblastosis foetalis. [RS Mar 05, P1]

SA:
1. Target cell. what is it? How does it look? [RS May 00, P1]
2. Name parasites causing anaemias. [OS Apr 01]
3. Peripheral blood smear findings in Iron deficiency anaemia. [RS Oct 03, P1]
4. Peripheral smear in Iron deficiency anaemia. [RS Dec 04, P1]
5. Megaloblast. [RS Mar 05, P1]
6. What is schilling test? [RS Nov 00, P1]
7. Abnormally low R.B.C. count is seen. Name the condition. [RS May 00, P1]
8. Name four haemoglobinopathies. [OS Sept 02]
9. Classification of thalassaemia. [RS Mar 05, P1]
10. Last the abnormal hemoglobins. [RS Nov 00, P1]
11. Definition And causes of leuco-erythroblastic Anaemia. [RS Mar 03, P1]
12. Leukocytosis. [RS Mar 06, P1]
13. What is leucopenia? What are the causes? [RS Nov 00, P1]
14. Leucopenia. What is it? Name the causes. [RS May 00, P1]
15. Definition and two causes of leucopenia. [RS Sept 02, P1]
16. Normal and abnormal absolute eosinophil count values. [RS May 00, P1]
17. Peripheral smear findings in acute myeloid leukaemia. [RS Mar 05, P1]
18. Peripheral smear findings in chronic myeloid leukaemia. [RS Mar 06, P1]
19. Special stains used to differentiate Leukaemoid reaction and Leukaemia.
[RS May 00, P1]
20. Enumerate the causes of thrombocytosis. [RS Oct 03, P1]
21. Etiopathogenesis of ITP. [RS Mar 06, P1]
22. Blood transfusion reactions. [RS Mar 06, P1]
23. Name Diseases transmitted by blood transfusion. [RS Oct 03, P1]

—————————
Syllabus:
Clinical Haematology:
[3] Study of Bone Marrow and Marrow transfusion.
[2] Theoretical aspects of b) Blood indices, e) Reticulocyte, f) Normal values in
haematology.
[4] Blood grouping: a) Concept of Blood Group, d) Blood Transfusion, reaction,
diseases transmitted by blood transfusion.SE:
1. Reticulocyte. [RS Mar 06, P1]
2. ABO blood group system. [OS Apr 01]
SA:
1. Name needles used for bone marrow biopsy. [RS Sept 02, P1]
2. Name red cell indices with normal values. RS Sept 02, P1]
3. Mean corpuscular volume. [OS May 00]
4. Mean corpuscular hemoglobin concentration. [RS Dec 04, P1]
5. Bombay blood group. [RS Oct 03, P1]
6. What is Rh blood grouping? [RS May 00, P1]

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3 Comments

  1. 2, September , 2006 at 4:41 am

    Describe the blood, structure & function of blood.

  2. 2, September , 2006 at 4:41 am

    Describe the Haematology.

  3. vijay said,

    17, July , 2007 at 7:52 am

    nice


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