Pharmacology (Revised Scheme) Oct 2002, Paper 1

1. Classify the benzodiazepines. Explain their mechanism of action pharmacokinetics and therapeutic uses. Mention their advantage over barbiturates as sedative-hypnotics.
2. Classify the antianginal drugs. Explain the mechanism of action, pharmacokinetics, adverse effects and the therapeutic uses of organic nitrates.

3. First pass metabolism and its pharmacokinetic implications.
4. Advantages and disadvantages of intravenous route.
5. Differences between morphine and pethidine.
6. Management of chronic alcoholism.
7. Drug therapy of cardiogenic shock.
8. Inhalational antiasthmatic drugs.
9. Advantages and disadvantages of halothane as general anesthetic.
10. Selective serotonin reuptake inhibitors (SSRIs).
11. Drug therapy of glaucoma.
12. Class III antiarrhytmic drugs.

13. Rifampicin reduces the efficacy of oral contraceptive pills.
14. Heparin is preferred to warfarin as anticoagulant during pregnancy
15. Rationale for the use of digoxin in atrial fibrillation.
16. Propranolol should not be combined with Verapamil in angina pectoris.
17. Ketamine is the ideal anaesthetic for shocked patients.
18. Sodium valproate is not suitable for children under 2 yrs.
19. Rationale for the use of Thiazide in diabetes insipidus.
20. Polypeptide drug are ineffective by mouth.
21. Urine should be alkalized in the management of acute barbiturate poisoning.
22. Rationale for using indomethacin in dysmenorrhea.
23. Clozapine is less likely to cause extrapyrimidal toxicity.
24. Allopurinol should not be used in acute gout.25. Use of N-acetyl cysteine in paracetamol poisoning.
26. Rationale for combining adrenaline along with local anaesthetics.
27. ACE inhibitors are contraindicated during pregnancy.
28. Heparin is quick acting but not warfarin sodium.

Question Paper Submitted by:
2003-04 Batch, BMC.


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